MCP server

Interpro

io.github.pipeworx-io/interpro

Checked 26 Oct 2026, 08:29 UTC · Connected to it and listed its tools

InterPro MCP (EBI) — protein family / domain / functional-site classification.

Website Source

At a glance

Type

MCP server

Publisher

pipeworx.io (verified by the MCP Registry)

Status

Working at last check

Tools

45

Token cost

About 26,840 tokens per request

Sets up in

Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok

Last checked

26 Oct 2026, 08:29 UTC

Connect it to your agent

Add to CursorAdd to VS CodeVS Code Insiders

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http interpro https://gateway.pipeworx.io/interpro/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.interpro]
url = "https://gateway.pipeworx.io/interpro/mcp"

Gemini CLI

{"mcpServers":{"interpro":{"httpUrl":"https://gateway.pipeworx.io/interpro/mcp"}}}

Cursor

{"mcpServers":{"interpro":{"url":"https://gateway.pipeworx.io/interpro/mcp"}}}

VS Code

{"servers":{"interpro":{"type":"http","url":"https://gateway.pipeworx.io/interpro/mcp"}}}

Antigravity

agy mcp add interpro https://gateway.pipeworx.io/interpro/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"interpro","server_url":"https://gateway.pipeworx.io/interpro/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"interpro","server_url":"https://gateway.pipeworx.io/interpro/mcp"}

Tools

• entries_for_protein ~147 tokens
  List all InterPro entries (families, domains, sites) found on a given UniProt protein, by UniProt accession (e.g. "P12345"). Returns each matching InterPro signature with accession, name and type. Useful to functionally annotate a protein. Complements UniProt/AlphaFold. Keyless.
• get_entry ~170 tokens
  Get full details for a single InterPro entry by accession (e.g. "IPR000001"). Returns the entry name, type, a plain-text description, member-signature/protein counters, and associated GO terms (molecular function / biological process / cellular component). Use after search_entries or entries_for_pro
• search_entries ~220 tokens
  Search InterPro for protein families, domains, repeats and functional sites by keyword (text search over entry names/accessions). InterPro is EBI's integrated protein-signature classification (Pfam, PROSITE, SMART, CDD, PANTHER, ...). Returns matching entries with accession (IPRxxxxxx), name, type (

Browse

• GitHub tools
• GitHub and code hosting

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