MCP server

Uniprot

io.github.pipeworx-io/uniprot

Checked 26 Oct 2026, 08:29 UTC · Connected to it and listed its tools

UniProt MCP — protein sequence + function database.

Website Source

At a glance

Type

MCP server

Publisher

pipeworx.io (verified by the MCP Registry)

Status

Working at last check

Tools

48

Token cost

About 27,395 tokens per request

Sets up in

Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok

Last checked

26 Oct 2026, 08:29 UTC

Connect it to your agent

Add to CursorAdd to VS CodeVS Code Insiders

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http uniprot https://gateway.pipeworx.io/uniprot/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.uniprot]
url = "https://gateway.pipeworx.io/uniprot/mcp"

Gemini CLI

{"mcpServers":{"uniprot":{"httpUrl":"https://gateway.pipeworx.io/uniprot/mcp"}}}

Cursor

{"mcpServers":{"uniprot":{"url":"https://gateway.pipeworx.io/uniprot/mcp"}}}

VS Code

{"servers":{"uniprot":{"type":"http","url":"https://gateway.pipeworx.io/uniprot/mcp"}}}

Antigravity

agy mcp add uniprot https://gateway.pipeworx.io/uniprot/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"uniprot","server_url":"https://gateway.pipeworx.io/uniprot/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"uniprot","server_url":"https://gateway.pipeworx.io/uniprot/mcp"}

Tools

• feature_summary ~151 tokens
  "Domain map of [protein]" / "annotated features of [accession]" / "what regions / sites does [protein] have" — annotated features (domains, active sites, transmembrane regions, mutagenesis sites, glycosylation, disulfide bonds, etc.) for a UniProt accession. Use for structural/functional analysis wi
• get ~198 tokens
  "Fetch protein [P12345]" / "UniProt entry for [accession]" / "FASTA sequence for [protein]" — single UniProtKB entry by accession (e.g. P12345 or P38398 for BRCA1_HUMAN). Returns full protein record: sequence, function annotations, GO terms, cross-refs, post-translational modifications, variants. Pa
• keyword ~110 tokens
  "UniProt keyword KW-N info" / "what does keyword [X] mean" — fetch a UniProt controlled-vocabulary keyword by ID. Use to look up annotation tags like "Kinase" / "Membrane" / "Disease-associated".
• proteomes_search ~134 tokens
  "Reference proteome for [organism]" / "complete protein set of [species]" — search UniProt reference proteomes (the curated representative protein set per organism). Use as a starting point for genome-scale protein analyses.
• search ~354 tokens
  "Find protein [name]" / "look up [gene] in UniProt" / "BRCA1 / TP53 / insulin protein info" / "all proteins for [organism]" — UniProtKB search via Lucene-style queries (e.g. gene:BRCA1 AND organism_id:9606 for human BRCA1). UniProt is the authoritative protein-sequence-and-function database — use fo
• taxonomy_search ~145 tokens
  "NCBI taxonomy ID for [organism]" / "taxid for [species]" / "look up [Latin name] in NCBI taxonomy" — search NCBI Taxonomy via UniProt's mirror. Returns taxonomic IDs you can use as organism_id filters in `search` (9606 = human, 10090 = mouse, 7227 = D. melanogaster, etc).

Browse

• GitHub tools
• GitHub and code hosting
• Databases
• Research papers

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