MCP server

Interpro

io.github.cyanheads/interpro-mcp-server

Checked 25 Oct 2026, 20:29 UTC · Connected to it and listed its tools

Search InterPro entries, map protein domains and functional sites, and find proteins by domain.

Source

At a glance

Type

MCP server

Publisher

Not verified

Status

Working at last check

Tools

6

Token cost

About 2,855 tokens per request

Sets up in

Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok

Last checked

25 Oct 2026, 20:29 UTC

Connect it to your agent

Add to CursorAdd to VS CodeVS Code Insiders

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http interpro-mcp-server https://interpro.caseyjhand.com/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.interpro-mcp-server]
url = "https://interpro.caseyjhand.com/mcp"

Gemini CLI

{"mcpServers":{"interpro-mcp-server":{"httpUrl":"https://interpro.caseyjhand.com/mcp"}}}

Cursor

{"mcpServers":{"interpro-mcp-server":{"url":"https://interpro.caseyjhand.com/mcp"}}}

VS Code

{"servers":{"interpro-mcp-server":{"type":"http","url":"https://interpro.caseyjhand.com/mcp"}}}

Antigravity

agy mcp add interpro-mcp-server https://interpro.caseyjhand.com/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"interpro-mcp-server","server_url":"https://interpro.caseyjhand.com/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"interpro-mcp-server","server_url":"https://interpro.caseyjhand.com/mcp"}

Tools

• interpro_find_proteins_by_domain ~657 tokens
  Find UniProt proteins carrying an InterPro or member signature. Defaults to reviewed human proteins; reviewedOnly=false includes all review statuses in the chosen taxon. Optional isFragment filters fragment annotations; false does not prove sequence completeness. architectureId intersects the provid
• interpro_get_clan ~522 tokens
  Retrieve a Pfam, CDD, or PIRSF clan/set and a cursor page of member entries; optionally include its relationship graph, returned in slices that fit the response budget and paged with relationshipOffset.
• interpro_get_entry ~527 tokens
  Retrieve one InterPro or member-database entry with full metadata by default. Select optional sections while retaining core and unknown metadata, or supply overlapLimit to page whole overlap records in upstream order; offsets are not a snapshot across calls.
• interpro_get_protein_domains ~460 tokens
  Retrieve InterPro and member-signature matches on a canonical UniProt protein, preserving every location and discontinuous fragment. Optionally select records covering a residue, include extra predicted features, and include functional residue rules with provenance. Budgeted segments hold whole reco
• interpro_list_reference ~147 tokens
  List supported InterPro database slugs, entry types, accession routing patterns, common taxon IDs, or current release information.
• interpro_search_entries ~542 tokens
  Search InterPro entries or member signatures by text or entry type. GO filters require sourceDatabase interpro; integratedInto selects member signatures for an InterPro accession. Results are cursor-paged; use interpro_get_entry for full metadata.

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