MCP server

Civic

io.github.pipeworx-io/civic

Checked 26 Oct 2026, 08:29 UTC · Connected to it and listed its tools

CIViC — Clinical Interpretation of Variants in Cancer.

Working at last checkOfficial: pipeworx.io's GitHub account (pipeworx-io)About 27,384 tokens per request once connected46 tools

https://gateway.pipeworx.io/civic/mcp

At a glance

Type: MCP server
Publisher: pipeworx.io (verified by the MCP Registry)
Status: Working at last check
Tools: 46
Token cost: About 27,384 tokens per request
Sets up in: Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok
Last checked: 26 Oct 2026, 08:29 UTC

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http civic https://gateway.pipeworx.io/civic/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.civic]
url = "https://gateway.pipeworx.io/civic/mcp"

Gemini CLI

{"mcpServers":{"civic":{"httpUrl":"https://gateway.pipeworx.io/civic/mcp"}}}

Cursor

{"mcpServers":{"civic":{"url":"https://gateway.pipeworx.io/civic/mcp"}}}

VS Code

{"servers":{"civic":{"type":"http","url":"https://gateway.pipeworx.io/civic/mcp"}}}

Antigravity

agy mcp add civic https://gateway.pipeworx.io/civic/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"civic","server_url":"https://gateway.pipeworx.io/civic/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"civic","server_url":"https://gateway.pipeworx.io/civic/mcp"}

civic_assertions ~256 tokens
CIViC assertions — the curated, AMP/ASCO/CAP-tiered and ACMG-classified clinical summaries that roll up multiple evidence items into a single actionable statement, including FDA companion-test and regulatory-approval flags. AUTHORITATIVE for "is this variant clinically actionable in this disease, an
civic_gene_variants ~219 tokens
Curated variants of a cancer gene in CIViC — the specific alterations (missense, fusion, amplification, exon-level) that have published clinical interpretations, each with its evidence count, associated diseases and therapies. AUTHORITATIVE for "which variants of this gene are clinically actionable"
civic_search_genes ~214 tokens
Find cancer genes and fusions in CIViC by name or symbol, with how much curated clinical evidence each carries (variant count, evidence-item count, assertion count). AUTHORITATIVE starting point for "what does CIViC know about gene X" — CIViC is the open expert-curated knowledgebase of clinically ac
civic_variant_evidence ~392 tokens
Individual CIViC evidence items for a molecular profile — the graded, source-linked statements that a variant predicts response or resistance to a therapy, carries prognostic or diagnostic weight, or is oncogenic. Each item carries evidence type, level (A-E), direction, significance, 1-5 star rating

Folklore Clinical Variant Interpretation MCP
Variant interpretation, gene-disease evidence, literature
Folklore Clinical Variant Interpretation MCP
Bioinformatics MCP for genomic variant interpretation, gene-disease evidence and literature.
Ensembl
Ensembl REST MCP.
OpenCancer
Cancer patient expert: NCCN-grounded answers with sources, recruiting trials, and expert review.
Cochrane Medical Reviews
Systematic medical reviews and evidence-based healthcare research
Health Data
Health data: NIH grants, WHO statistics, and genetic variants
Myvariant
MyVariant.info MCP. Aggregated human genetic-variant annotation: dbSNP, ClinVar clinical…
The Gastrologer — GI clinical tools for agents
Physician-governed GI tools: claim verification, teaching retrieval, HRM and instrument scoring

[![AptLynx](https://aptlynx.net/badge/io.github.pipeworx-io/civic.svg)](https://aptlynx.net/servers/io.github.pipeworx-io/civic)

Listing text is written by the maker; AptLynx lists tools and does not vouch for them. Find another tool · Browse by topic · For agents