MCP server

Chembl

io.github.pipeworx-io/chembl

Checked 26 Oct 2026, 08:29 UTC · Connected to it and listed its tools

ChEMBL MCP — drug discovery database (EBI).

From the maker's README ChEMBL MCP — drug-discovery database from EBI: bioactive molecules, drug targets, mechanism of action, clinical phases. Keyless. Source

Website Source

At a glance

Type

MCP server

Publisher

pipeworx.io (verified by the MCP Registry)

Status

Working at last check

Tools

49

Token cost

About 27,695 tokens per request

Sets up in

Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok

Last checked

26 Oct 2026, 08:29 UTC

Connect it to your agent

Add to CursorAdd to VS CodeVS Code Insiders

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http chembl https://gateway.pipeworx.io/chembl/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.chembl]
url = "https://gateway.pipeworx.io/chembl/mcp"

Gemini CLI

{"mcpServers":{"chembl":{"httpUrl":"https://gateway.pipeworx.io/chembl/mcp"}}}

Cursor

{"mcpServers":{"chembl":{"url":"https://gateway.pipeworx.io/chembl/mcp"}}}

VS Code

{"servers":{"chembl":{"type":"http","url":"https://gateway.pipeworx.io/chembl/mcp"}}}

Antigravity

agy mcp add chembl https://gateway.pipeworx.io/chembl/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"chembl","server_url":"https://gateway.pipeworx.io/chembl/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"chembl","server_url":"https://gateway.pipeworx.io/chembl/mcp"}

Tools

• activities ~181 tokens
  Retrieve bioactivity records from ChEMBL filtered by molecule_chembl_id and/or target_chembl_id; returns IC50/Ki/EC50 values, assay descriptions, and units. This is SMALL-MOLECULE assay data: a biologic such as an antibody has none by construction, and the response says so rather than returning a ba
• chembl_mechanism ~628 tokens
  Mechanism of action of a drug, from its NAME (or a ChEMBL molecule ID). Answers "how does metformin work", "what is the mechanism of action of X", "what does X inhibit", "what target does X act on", "X mode of action", "is X an agonist or an antagonist", "X molecular target". Resolves the drug name
• drug_indications ~120 tokens
  Retrieve approved drug indication records from ChEMBL filtered by molecule_chembl_id and/or MeSH disease ID; returns disease names, efo_id cross-references, and max clinical trial phase.
• mechanism ~132 tokens
  Raw ChEMBL mechanism records for one exact molecule ChEMBL ID (e.g. "CHEMBL1703"), returned verbatim from the API. Use when you already hold the precise molecule ID and want the unshaped rows; to start from a drug name, call `chembl_mechanism`.
• molecule ~69 tokens
  Full molecule record by ChEMBL ID (e.g. "CHEMBL25" = aspirin).
• search ~202 tokens
  Full-text search the ChEMBL drug-discovery database for molecules, targets, assays, or documents; returns ChEMBL IDs and summary fields you can pass to `molecule`, `target`, or `activities`. Pair with `chembl_mechanism`, which takes a drug name directly and returns its mechanism of action and target
• target ~60 tokens
  Target record by ChEMBL target ID.

Browse

• GitHub tools
• GitHub and code hosting
• Databases
• Research papers
• Health and medicine

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