MCP server

Rhea

io.github.pipeworx-io/rhea

Checked 26 Oct 2026, 08:29 UTC · Connected to it and listed its tools

Rhea MCP — expert-curated database of biochemical reactions.

Website Source

At a glance

Type

MCP server

Publisher

pipeworx.io (verified by the MCP Registry)

Status

Working at last check

Tools

44

Token cost

About 26,652 tokens per request

Sets up in

Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok

Last checked

26 Oct 2026, 08:29 UTC

Connect it to your agent

Add to CursorAdd to VS CodeVS Code Insiders

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http rhea https://gateway.pipeworx.io/rhea/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.rhea]
url = "https://gateway.pipeworx.io/rhea/mcp"

Gemini CLI

{"mcpServers":{"rhea":{"httpUrl":"https://gateway.pipeworx.io/rhea/mcp"}}}

Cursor

{"mcpServers":{"rhea":{"url":"https://gateway.pipeworx.io/rhea/mcp"}}}

VS Code

{"servers":{"rhea":{"type":"http","url":"https://gateway.pipeworx.io/rhea/mcp"}}}

Antigravity

agy mcp add rhea https://gateway.pipeworx.io/rhea/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"rhea","server_url":"https://gateway.pipeworx.io/rhea/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"rhea","server_url":"https://gateway.pipeworx.io/rhea/mcp"}

Tools

• get_reaction ~149 tokens
  Fetch a single Rhea reaction by its Rhea id (e.g. "RHEA:14293" or "14293"). Returns the balanced plain-text equation plus EC number, ChEBI compound, UniProt enzyme and PubMed cross-references. Rhea is the expert-curated biochemical reaction reference used by UniProt and KEGG. Keyless.
• search_reactions ~200 tokens
  Search Rhea, the expert-curated database of biochemical reactions (the reaction reference used by UniProt and KEGG). Find enzyme/metabolic reactions by compound name, ChEBI id, EC number, or keyword and get the balanced plain-text reaction equation plus EC and ChEBI cross-references. Keyless.

Browse

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