MCP server

Hpo Api

io.github.pipeworx-io/hpo-api

Checked 26 Oct 2026, 08:29 UTC · Connected to it and listed its tools

HPO API MCP.

Website Source

At a glance

Type

MCP server

Publisher

pipeworx.io (verified by the MCP Registry)

Status

Working at last check

Tools

49

Token cost

About 27,224 tokens per request

Sets up in

Claude Code, Claude Desktop, Codex, Gemini CLI, Cursor, VS Code, Antigravity, ChatGPT, OpenAI API, Grok

Last checked

26 Oct 2026, 08:29 UTC

Connect it to your agent

Add to CursorAdd to VS CodeVS Code Insiders

Opens the app, which shows the server and asks you to confirm. For other apps, copy the setup below.

Claude Code

claude mcp add --transport http hpo-api https://gateway.pipeworx.io/hpo-api/mcp

Claude Desktop

Settings → Connectors → Add custom connector, and paste the URL.

Codex (config.toml)

[mcp_servers.hpo-api]
url = "https://gateway.pipeworx.io/hpo-api/mcp"

Gemini CLI

{"mcpServers":{"hpo-api":{"httpUrl":"https://gateway.pipeworx.io/hpo-api/mcp"}}}

Cursor

{"mcpServers":{"hpo-api":{"url":"https://gateway.pipeworx.io/hpo-api/mcp"}}}

VS Code

{"servers":{"hpo-api":{"type":"http","url":"https://gateway.pipeworx.io/hpo-api/mcp"}}}

Antigravity

agy mcp add hpo-api https://gateway.pipeworx.io/hpo-api/mcp

ChatGPT

Settings → Apps & Connectors → Advanced settings: turn on Developer mode, then Create a connector and paste the URL. Which plans can do this varies.

OpenAI API (Responses tools)

{"type":"mcp","server_label":"hpo-api","server_url":"https://gateway.pipeworx.io/hpo-api/mcp","require_approval":"always"}

Grok (xAI API tools)

{"type":"mcp","server_label":"hpo-api","server_url":"https://gateway.pipeworx.io/hpo-api/mcp"}

Tools

• disease_phenotypes ~142 tokens
  "What symptoms / clinical features does [disease] cause" / "HPO phenotypes for [OMIM N]" / "clinical signs of [rare disease]" — list HPO phenotype terms for a disease ID (OMIM:N, ORPHA:N, or MONDO:N format). Use to enumerate clinical features of rare diseases. Example ID: OMIM:154700 (Marfan syndrom
• gene_diseases ~131 tokens
  "What diseases is gene [NCBIGene:N] associated with" / "diseases linked to gene [X]" / "TP53 disease associations" — fetch diseases associated with a gene ID (NCBIGene:N format). Use for gene-to-disease lookups in rare-disease research, variant prioritization. Example ID: NCBIGene:7157 (TP53).
• search ~185 tokens
  "HPO term for [symptom]" / "phenotype code for [clinical sign]" / "find HPO IDs about [feature]" / "what's the HPO for seizures / autism / short stature" — text search the Human Phenotype Ontology (HPO). Returns ranked terms with HP: IDs. Use to map clinical descriptions to standard ontology terms f
• term ~133 tokens
  "What does HP:[N] mean" / "look up HPO phenotype [ID]" — fetch a single Human Phenotype Ontology (HPO) term by ID. HPO is the standard ontology for clinical phenotypes used in rare-disease research. Returns label, definition, synonyms, cross-references. Example ID: HP:0001250 (Seizure).
• term_children ~120 tokens
  "More specific HPO phenotypes under [HP:N]" / "child terms of [phenotype]" — direct children of an HPO term in the ontology graph. Use to narrow from a general phenotype (e.g. "Abnormality of the nervous system") to specifics (seizures, ataxia, etc).
• term_descendants ~113 tokens
  "All phenotypes under [HP:N]" / "full subtree of [HPO term]" — transitive descendants (children, grandchildren, …) of an HPO term. Use for exhaustive coverage (e.g. "every cardiac phenotype" via descendants of HP:0001626).
• term_parents ~97 tokens
  "What broader phenotype is [HP:N] under" / "parent term of [HPO ID]" — direct parents of an HPO term in the ontology graph. Use to walk up to a more general phenotype class.

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